Essay topic 5. Neuromuscular junction as site of disease process. AND Formation of Nuromuscular junction.

Essay topic 5. 5. The neuromuscular occasion as a post of disease process Proteins involved in organisation of the neuromuscular join The neuromuscular junction is a severalise junction, where a labour marrow forms its synaptic terminal with a muscle eccentric, one of umteen fibres that make up a whole muscle. The mature neuromuscular junction is composed of three types of cells - a motor kernel terminal, a muscle fibre and a Schwann cell c all in all over the junction. exclusively three of these cells argon highly differentiated and specialized for their functions (Kandel 2000, p. 1089). The events that materialize during the formation of the neuromuscular junction have been extensively analyse and are the most comprehensively understood of any nerve-to-tar extend cell contact. Prior to formation of the synapse all three components of the neuromuscular junction develop and acquire identities independently. The muscle cells are derived from the mesoderm and reincarnate from the dermomyotomal portion of the somite. Motoneurons migrate from the ventricular zone of the neural electric resistance to a ventral-lateral location before axons grow out of the spinal anesthesia anesthesia cord. Schwann cells are glial cells, which insulate the axons outside of the spinal cord, they are derived from neural crest cells and associate with axons from the somite in the lead to the peripheral device target.

At the time of the first axons range the developing muscle, the muscle fibres are myoblasts that have just amalgamate to form multinucleated myotubes, there is no evidenc e to suggest that motor neurons prefer certa! in situate on the developing myotube or that there is a determine site for the formation of the synapse, on the contrary, synapse formation can occur on most, if not all of the myotube surface (Lichtman et al in Zigmond et al 2000, pp. 547-8). Acetylcholine receptors (AChR) are tack together uniformly dispersed over the surface of the... If you want to get a full essay, ordinate it on our website: OrderCustomPaper.com

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